44% of lesions showed > 85% reduction in size & mean reduction was 71%; 7% of lesions failed to respond. Most residual lesions showed actinic atypia without cancer & were treated with cyrotherapy…
A 30% Ascorbic Acid Solution in DMSO Reduced the Need for Surgery in 94% of Cutaneous Squamous Cell Carcinoma in Situ Patients
Briant Burke, MD, MS
Medical Director Boise Research Foundation
967 E. Parkcenter Blvd, Ste 205
(208) 353-0158
bburkemd2@gmail.com
“Topical 30% Ascorbic Acid in Dimethyl Sulfoxide
for the Treatment of Cutaneous Squamous Cell Carcinoma In Situ.”
medRxiv 2025.10.13.25337920 (PDF)
(10/2026)
Interview Summary…
Dr. Briant Burke described a longstanding interest in integrative medicine, natural products, and research, rooted in his background in neuroscience and molecular biology and influenced by his mother’s experience with cancer. He said he believes potentially useful treatments should not be dismissed simply because they are natural or considered unconventional, particularly because such approaches may be low-tech, inexpensive, and safe.
Vitamin C & DMSO as A Skin Cancer Treatment…
His interest in topical vitamin C and DMSO developed from an earlier experience treating basal cell carcinoma. After finding an older study using concentrated vitamin C as a paste that required lengthy treatment, he looked for a way to improve penetration and considered DMSO. After seeing Continue reading A 30% Ascorbic Acid Solution in DMSO Reduced the Need for Surgery in 94% of Cutaneous Squamous Cell Carcinoma in Situ Patients→
